重组MICAL样蛋白2
交货期：1周
产品别名：Recombinant MICALL2
Recombinant MICAL like 2 protein
Recombinant MICAL like 2 protein
基因名：
产品别名：
背景信息：
MICALL2
产品别名：
JRAB； MICAL-L2； MICALL2； MICAL like 2； MICAL like 2； MICAL-like protein 2； junctional Rab13-binding protein； molecule interacting with CasL-like 2； MICAL样蛋白2；
背景信息：
JRAB is a 904 amino acid protein with one CH (calponin-homology) domain and one LIM zinc-binding domain. JRAB has been shown to interact with Rab13 and Rab8 to facilitate cellular transport of claudin-1, occludin, and E-cadherin. This interaction is vital for the coordination of the assembly of tight junctions (TJs) and adherens junctions (AJs). Dynamic turnover (endocytic recycling) of cell-to-cell AJs and TJs is essential for epithelial morphogenesis during normal development and differentiation. The endocytic recycling of occludin and cluadin proteins is part of an ongoing process of restructuring and maintaining cell junctions, especially at TJs. JRAb and Rab13 have also been implicated in the carcinoma metastasis event of epithelial cell scattering. This event shows Rab13 and JRAB colocalizing with F-Actin in lamellipodial structures prior to cell scattering.
产品发布日期：2025.08.12
广州伟伯科技有限公司