磷酸肌醇相互作用蛋白抗体
交货期：1周
产品别名：Anti-Pirt
Anti-phosphoinositide-interacting regulator of transient receptor potential channels Antibody
Anti-phosphoinositide-interacting regulator of transient receptor potential channels Antibody
靶标：
产品别名：
背景信息：
Pirt
产品别名：
A530088H08Rik； Pirt； phosphoinositide-interacting regulator of transient receptor potential channels； phosphoinositide-interacting regulator of transient receptor potential channels； phosphoinositide-interacting protein； 磷酸肌醇相互作用蛋白；
背景信息：
PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1.
产品发布日期：2025.06.30
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