PILRA抗体
交货期：1周
产品别名：Anti-PILRA
Anti-paired immunoglobin like type 2 receptor alpha Antibody
Anti-paired immunoglobin like type 2 receptor alpha Antibody
靶标：
产品别名：
背景信息：
PILRA
产品别名：
FDF03； PILRA； paired immunoglobin like type 2 receptor alpha； paired immunoglobin like type 2 receptor alpha； paired immunoglobulin-like type 2 receptor alpha； cell surface receptor FDF03； inhibitory receptor PILR-alpha；
背景信息：
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
产品发布日期：2025.07.10
广州伟伯科技有限公司