ZNF774 (zinc finger protein 774) is a 483 amino acid protein that localizes to the nucleus and contains 12 C2H2-type zinc fingers and a KRAB domain. One of several members of the Krüppel C2H2-type zinc-finger protein family, ZNF774 is thought to be involved in transcriptional regulation events. The gene encoding ZNF774 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

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