连接介导调节蛋白抗体
交货期:1周
产品别名:Anti-Jmy
Anti-junction-mediating and regulatory protein Antibody
靶标:
Jmy
产品别名:
Jmy; junction-mediating and regulatory protein; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY; 连接介导调节蛋白;
背景信息:
function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.,
产品发布日期:2026.09.05